Formacija i destrukcija domena u vodenim otopinama

Opis projekta
The physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn't been explored as such in similar research projects. In the project's first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn't propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group's acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.

Akronim
MS-FORMDES

Šifra projekta
UIP-2013-11-4514

Poziv
UIP-2013-11

Vrsta projekta
Znanstveno-istraživački

Vrsta financiranja
Kompetitivno projektno financiranje

Financijer
HRZZ - Hrvatska zaklada za znanost

Detalji financiranja
 UIP - Uspostavni istraživački projekti

Ukupan iznos financiranja projekta
653.750,00 HRK

Trajanje projekta
2014-09-15 - 2017-12-14

Ustanova - uloga
Prirodoslovno-matematički fakultet, Split - Nositelj (653.750,00 HRK)

Osoba - Ustanova - uloga [pocetak - zavrsetak]
Larisa Zoranić (MBZ: 254280, CROSBI: 30060) - nema - Voditelj projekta [2014-09-15 - 2017-12-14]
Martina Požar (MBZ: 361905, CROSBI: 34135) - Prirodoslovno-matematički fakultet, Split - Suradnik [2014-09-15 - 2017-12-14]
Bernarda Lovrinčević (MBZ: 317322, CROSBI: 32232) - Prirodoslovno-matematički fakultet, Split - Suradnik [2014-09-15 - 2017-12-14]
Tomislav Rončević (MBZ: 364552, CROSBI: 34395) - Prirodoslovno-matematički fakultet, Split - Suradnik [2014-09-15 - 2017-12-14]
Nada Ilić (MBZ: 297572, CROSBI: 24217) - Prirodoslovno-matematički fakultet, Split - Suradnik [2014-09-15 - 2017-12-14]
Franjo Sokolić (MBZ: 65502, CROSBI: 27006) - Prirodoslovno-matematički fakultet, Split - Suradnik [2014-09-15 - 2017-12-14]