Opis projekta
This project will investigate how pleitropy (the effect of one gene on multiple phenotypic traits), gene networks and gene pathways are determining a number of clinically relevant quantitative traits. Primary research focus is on the genetic basis of body shape and facial features, based on an innovative approach to produce large number of measurements from the 3-dimensional body and face scanning. In order to achieve this aim, we will perform 3D scanning of 2,000 healthy subjects from the island of Korcula, within one of the largest biomedical research resources in Croatia – the 10,001 Dalmatians biobank. Besides excellent genotyping and sequencing opportunities, the inclusion of subjects from the isolated island populations facilitates gene discovery and enables the search for the rare genetic variants. After completion of genome-wide association and exome analysis, we will also use gene networking and pathway analysis tools, as well as the advanced analytic tools, such as random forest, lasso regression, partial least squares regression and latent class analysis in order to produce results that can be translated to clinical medicine, fitness and beauty, as well as legal medicine and forensics. Progress over the existing research designs will also be achieved by inclusion of extensive confounding information and family structure into analysis. All these findings will also be investigated in follow-up measurements and linked with the morbidity and mortality information in the future, thus further developing a coherent resource capable of producing highly competitive research results. With the excellent track record of the principal investigator, outstanding institutional support and well-established research team experienced in computational genomics and field work, this project will provide a substantial step forward over the existing state-of-the-art studies that rely on simple genomic associations, yet manage to publish their results in the top-end journals.
Šifra projekta
HRZZ-IP-11-2013-8875
Poziv
HRZZ
Vrsta projekta
Znanstveno-istraživački
Vrsta financiranja
Kompetitivno projektno financiranje
Financijer
HRZZ - Hrvatska zaklada za znanost
Detalji financiranja
IP - Istraživački projekti
Ukupan iznos financiranja projekta
961.000,00 HRK
Trajanje projekta
01-07-2014 - 30-06-2018
Ustanova - uloga
Medicinski fakultet, Split - Nositelj (961.000,00 HRK) [01-07-2014 - 30-06-2018]
Osoba - Ustanova - uloga [pocetak - zavrsetak]
Ozren Polašek
(MBZ: 271725,
CROSBI: 23335) - Medicinski fakultet, Split - Voditelj projekta [01-07-2014 - 30-06-2018]
Ivana Kolčić
(MBZ: 271736,
CROSBI: 22792) - Medicinski fakultet, Split - Suradnik [01-07-2014 - 30-06-2018]
